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When I first started taking Hydroxyurea it made me a little sick. Yet, after about 2 weeks I noticed a slight increase in energy and went from having a hospitalization crisis every 2-3 months to about ONCE a year. I still take pain meds for the smaller pains but my lifestyle had gotten MUCH better. I would recommend it to any person with sickle cell.

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Cancer is a really serious disease and the worse when doctor tells you that you have 6 months to live without chemeo and 12 months to live after chemeo.

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Alternatives to hydroxyurea that reduce morbidity are hematopoietic stem-cell transplantation and long-term transfusion therapy.

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System-level barriers to hydroxyurea treatment for sickle cell disease include 1) financing (lack of insurance, type of insurance, underinsurance, scope of coverage, co-pays, reimbursement, payment structures); 2) geographic isolation; 3) lack of coordination between academic centers and community-based clinicians; 4) limited access to comprehensive care centers and comprehensive care models; 5) problems in transitioning from pediatric to adult care; 6) limited access (for example, geographic distribution, recruitment, and retention of clinicians competent in the provision of comprehensive care to patients who have sickle cell disease); 7) inadequate government, industry, and philanthropic support for the care of patients with sickle cell disease; 8) slow development and promotion of hydroxyurea because of lack of commercial interest; 9) lack of visibility and empowerment of sickle cell disease advocacy groups; 10) cultural and language barriers to the provision of appropriate care; and 11) inadequate information technology systems to support the long-term care of patients with sickle cell disease.

Gleevec should be taken with food and a large glass of water to minimize the risk of stomach gastrointestinal irritation.

This article summarizes the role of vascular inflammation and coagulation activation, discusses potential mechanisms responsible for activation of coagulation and reviews recent data demonstrating the crosstalk between coagulation and vascular inflammation in sickle cell disease.

The National Institutes of Health funds sickle cell research centers, and several states currently support sickle cell specialty clinics.

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Make sure patient drinks 10 to 12 glasses of water daily.

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