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If you are prescribed this drug, ensure that you disclose all medications, supplements, and vitamins you regularly take with your doctor and pharmacist. Be aware of the following drug interactions:

Acetazolamide, sodium bicarbonate, and hydrochlorothiazide: These drugs may cause an increase in side effects by decreasing urinary excretion of Adderall.

Entacapone: The effects of dopamine, noradrenaline, and adrenaline are increased when administered with this drug.

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Antihistamines (diphenhydramine): The sedative effects of diphenhydramine are decreased when taken with this medication.

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