Methadoneis a prescription medication, which sold under the brand name Dolophine among others. It is an opioid medication specially used for opioid maintenance therapy in opioid dependence and also for the treatment of Chronic Pain. Sometimes, an opioid is also known as a narcotic. You may buy Methadone online too for the management of heroin withdrawal symptoms.

It was developed in Germany around the Year 1937 to 1939 by Max Bockmuhl and
Gustav Ehrhart. Methadone was approved for medical use in the United States in 1947.
According to the world health organization’s list of essential medicines, Methadone is
the most effective and safe medicine needed in the health system.

Types Of Methadone:

1. Methadone 10 mg

2.Methadone 5 mg

Instructions for usage?

· You should take the lowest effective dosage for the shortest duration as administered and prescribed by your doctor.

· You are advised to initiate your treatment with the lowest dosage, which you can increase gradually during the therapy

· The professionals should administer your dosage and, based on their physical, mental, and medical conditions.

Adverse effects of Methadone?

i. Withdrawal symptoms:

When you stop taking the medication suddenly after long-term treatment. There are
some chances of withdrawal symptoms, which may include the following.

· Anxiety
· Restlessness
· Tiredness
· Water eyes
· Runny nose
· Sweating
· Trouble sleeping
· Yawning
· Vomiting
· Muscle aches and pains
· Diarrhea
· Depression
· Drug cravings.
Black box warning
Methadone has some US FDA black box warnings which are following,
· Risk of abuse and addiction
· Lethal overdose in accidental ingestion
· Potentially fatal respiratory depression
· Risks when used with other drugs or alcohol, etc.

1. Overdose

Taking more frequent or more than require dosage may cause some severe adverse
effects including,

· Confusion.
· Dizziness often leads to falls or injuries.
· The painful intestine or stomach spasm
· Drowsiness can lead to severe accidents such as car wrecks or falls.
· Violent bouts of nausea.
· Severe constipation.
· Severe fatigue.
· Generalized weakness throughout the body that makes it challenging to walk stand, or
even move.
· Uncontrolled muscle twitches
· Profoundly slow, painful, or dangerously shallow breathing.
· The presence of blue fingernails and lips, indicating a lack of oxygenated blood.
· Breathing stops completely.
· A sharp drop in blood pressure.
· Cold, clammy skin, indicating your body is going into shock.
· A barely detectable pulse.
· Coma, etc.

1. Side effects?

There are some frequent and severe side effects of using Methadone, which may occur in some adverse conditions. Some unknown incidence:
· Black, tarry stools
· bleeding gums
· blood in the urine or stools
· blurred vision
· bulging soft spot on the head of an infant
· dizziness
· change in the ability to see colors, especially blue or yellow
· nausea
· variations in skin color
· chest discomfort or pain
· confusion
· convulsions
· cough
· coughing that sometimes produces a frothy pink sputum
· vomiting
· decreased urine output
· difficult or troubled breathing
· difficult, fast, noisy breathing, sometimes with wheezing
· difficulty with swallowing
· dilated neck veins
· increased sweating
· increased thirst
· irregular heartbeat
· irregular, fast or slow, or shallow breathing
· loss of appetite
· muscle pain or cramps
· pain
· pale or blue lips, fingernails, or skin
· pinpoint red spots on the skin
· puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
· sweating
· swelling of the face, fingers, feet, or lower legs
· tenderness
· trouble sleeping
· trouble urinating
· unusual bleeding or bruising
· unusual tiredness or weakness
· weight gain, etc.
The above-given lists do not contain all the adverse effects of Methadone. Some other specific symptoms may also possible; you are advised to take medical help if you have any abnormal changes while using Methadone.

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