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Pharmacology. These drugs have very similar effects to angiotensin converting enzyme (ACE) inhibitors and are used for the same indications (hypertension, heart failure, post- myocardial infarction).Their mechanism of action, however, is very different from ACE inhibitors, which inhibit the formation of angiotensin II.
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Indian Journal of Pharmacology (ISSN 0253-7613) is an official publication of the Indian Pharmacological Society. The first issue of the journal came out in 1969 and in 1997 it was published Bimonthly. IJP publishes original research articles, reviews, research letters and correspondences. download
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Pharmacology. ACE inhibitors produce vasodilation by inhibiting the formation of angiotensin II. This vasoconstrictor is formed by the proteolytic action of renin (released by the kidneys) acting on circulating angiotensinogen to form angiotensin I. Angiotensin I is then converted to angiotensin II by
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clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time; the usual units are mL/min. The quantity reflects the rate of drug elimination divided by plasma concentration.. The total body
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