Monobenzone exerts a permanent and irreversible depigmenting effect, whose mechanism of action acts on melanocytes, reducing melanin segregation. Available studies show that Monobenzone increases the production of melanin in melanocytes. It increases the degradation of melanosomes, inhibits tyrosinase, and destroys membranous organelles.

The mono benzyl ester of hydroquinone is a depigmenting agent that produces permanent depigmentation. It was excluded from its use in conventional depigmenting treatments, reserving only for permanent depigmentation of residual body areas in patients. However, it is a resource that, although valued by the prescribers, has little documentation on results and form of application.

From the statistical point of view, 75% of those who use the treatment are women, predominantly dark-skinned people, with an average duration of vitiligo of 15 years and that in more than 80% has a greater affectation of 50% of the body surface.


From the galenic point of view, the recommended dosage of Benoquin is 20% but can range between 15-30%. In this case, the recommended vehicle in facial areas is low-fat emulsions, given the irritating potential MB. Gels and cream-gels would not be suitable options for most patients. In body or hand areas more fat emulsions may be suitable

Monobenzone can be used for the following skin problems.


  • To attenuate and recover the natural color of the skin when it has been exposed to itself. Melanocytes are responsible for the pigmentation of our skin, but when it is exposed to the sun, the melanocytes produce more melanin to protect it from UV rays. First degree burns caused by the sun usually darken the skin permanently.
  • To lighten the skin to the desired color tone. The skin can be clarified further by decreasing the cells that give the pigment to the skin ( melanocytes ) so that a clear and natural color can be achieved with the use of monobenzone.
  • Monobenzone Cream can be used by people who suffer from extensive vitiligo. Vitiligo is a degenerative skin sickness in which the melanocytes die. The disease produces melanin in the area where cell death has occurred. People who suffer from this disease in more than 60% of the skin obtain to reduce their color and depigment the areas of their body that are not affected to achieve a uniform color.
  • For dark spots on the skin, they are often due to hyperpigmentation problems.The term hyperpigmentation refers to skin that has darkened more than normal, without the change being related to sun exposure. Melanocytes can become abnormal due to certain conditions and cause excessive darkening of skin color.
  • To disappear freckles that are given by inheritance. People with light skin, eyes, and hair are usually prone to them and intensify with sun exposure. Freckles are not eliminated but are clarified since their appearance is due to a genetic factor. Freckles and moles come out when the melanocytes grow in groups. They begin to be considered dangerous when they change in size and appearance, becoming melanomas.
  • For moles that are any dermal alteration that presents pigmentation differences for most of the skin, for this reason, other similarly external plasmas such as nevus, angiomas, and even certain aspects of melanomas and keratosis are called moles.

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