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Posted by Violetta on April 24, 2024 at 10:13am 0 Comments 0 Likes
Posted by Marc on April 24, 2024 at 10:13am 0 Comments 0 Likes
Monobenzone exerts a permanent and irreversible depigmenting effect, whose mechanism of action acts on melanocytes, reducing melanin segregation. Available studies show that Monobenzone increases the production of melanin in melanocytes. It increases the degradation of melanosomes, inhibits tyrosinase, and destroys membranous organelles.
The mono benzyl ester of hydroquinone is a depigmenting agent that produces permanent depigmentation. It was excluded from its use in conventional depigmenting treatments, reserving only for permanent depigmentation of residual body areas in patients. However, it is a resource that, although valued by the prescribers, has little documentation on results and form of application.
From the statistical point of view, 75% of those who use the treatment are women, predominantly dark-skinned people, with an average duration of vitiligo of 15 years and that in more than 80% has a greater affectation of 50% of the body surface.
From the galenic point of view, the recommended dosage of Benoquin is 20% but can range between 15-30%. In this case, the recommended vehicle in facial areas is low-fat emulsions, given the irritating potential MB. Gels and cream-gels would not be suitable options for most patients. In body or hand areas more fat emulsions may be suitable
Monobenzone can be used for the following skin problems.
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