Is dermal filler safe? Dermal fillers are considered to be safe but side effects can occur. A licensed healthcare professional should perform all dermal filler procedures using only FDA-approved fillers injected with a syringe. The most common problems include: skin rash, itching, or pimple-like eruptions. Botox derives from C. botulinum bacteria, which are present in many natural settings, including soil, lakes, forests, and the intestinal tracts of mammals and fish. Naturally occurring C.…See More