Supplementation of l‐arginine increases the therapeutic efficiency of anticancer chemoimmunotherapy

Myeloid‐derived suppressor cells (MDSCs) play a critical duty in immunosuppression in tumor‐bearing hosts. MDSCs share arginase‐I as well as indoleamine 2,3 dioxygenase; they reduce T‐cell function by minimizing the levels of l‐arginine and also l‐tryptophan, respectively. We examined the anticancer results of supplements of these amino acids in CT26 colon…