How to treat Her2 Neu positive breast cancer?

Chemotherapy cannot be avoided for such type of breast cancer unless tumor is less that 1cm. These are aggressive types of breast cancer and need targeted therapy along with chemotherapy.

Now different types of targeted therapies are available for such type of breast cancer and prognosis has improved with advent of targeted therapies like Trastuzumab, Pertuzumab, Trstuzumab Emtasine (TDM-1), Lapatinib, Fam-Trastuzumab, Tucatinib, Enhertu (chemical name: fam-trastuzumab-deruxtecan etc.

C, TNBC-Triple negative Breast cancer- Tumor which is ER Negative, PR Negative and Her2Neu negative are called triple negative breast cancer. Triple negative Breast cancer is an aggressive cancer and has more like spread at the time of diagnosis and is more likely to come back after treatment.

In early stage 5 year survival rate is 90%, for breast cancer patients who are locally advanced (Stage II, Stage III) 5 year survival is 60% and for stage IV triple negative breast cancer patient 5 year survival is 10%.

These cancers are usually associated with BRCA 1 and BRCA 2 genes and other hereditary syndromes as well. So such breast cancer patients are diagnosed at early age. Some body diagnosed with Triple negative breast cancer should be screened for Hereditary syndromes after proper genetic counselling.

Treatment has not changed much as no targeted therapy is available for treatment of TNBC breast cancer patients. Immunotherapy is a new tool which is showing promise.

Immunotherapy for Triple negative Breast Cancer-Immunotherapy has changed the way we look at triple negative breast cancer. Different drugs called immune checkpoint inhibitors are available and are in early phase trials, have shown promising results

Immunotherapy for breast cancer can be combined with chemotherapy especially for locally advanced breast cancer. In neo adjuvant settings it has shown good results in disease control for the first time in history. Research is going on and different clinical trials are addressing this issue.

Sofa we have seen more complete pathological responses with this approach.

C, TNBC-Triple negative breast cancer;- Tumor which is ER-Negative, PR-Negative and Her2Neu-Negative. -Aggressive type of breast cancer with high relapse rates .Now different drugs are available to cure this type of cancer. Immunotherapy is now a major tool to fight breast cancer.

Treatment of metastatic Breast cancer

Stage 4 breast cancer means that it is not curable, but that does not mean that breast cancer patients do not survive longer.

With newer drugs, better diagnostic techniques and better imaging modalities majority patients with stage 4 breast cancer survive beyond 5 years .

Again before starting treatment, we need to look at Estrogen receptor, Progesterone receptor and Her2Neu receptor status.

For ER, PR positive cancer patients and HerNeu negative there is no need for chemotherapy, these patients can forgo chemotherapy and can be treated with hormonal therapy (Tamoxifen, Letrazole, Anastrazole, Exemestene) and other newer drugs called CDK4,6 Inhibitors (Palbociclib, Abemaciclib, Everolimus, Fulvestrant etc) .

For Her2 Neu metastatic breast cancer patient newer drugs have shown promise in increasing survival.

For TNBC -Triple negative breast cancer survival remains poor and immunotherapy has shown promising results and more research is needed in this field.

Want to read to more about Breast cancer

1, Early detection of Breast cancer

2, Breast cancer screening

3, Sub types of Breast cancer

4, Treatment of high-risk breast cancer patients

5, Surgery for Breast cancer

Read More >> https://www.drwaseemabbas.com/breast-cancer-treatment-delhi-india-2/