The drug Carfilzomib is a sterile, white to off-white lyophilized powder, and it is a modified tripeptidyl epoxide isolated as the crystalline-free base. Carfilzomib is a tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds to the N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core particle within the 26S proteasome. This drug is used in the treatment of multiple myeloma and the patient who has received at least a couple of prior therapies, including bortezomib and an immunomodulatory agent. Carfilzomib single-use vials come in the standard strength of 60 mg to administer intravenously. Carfilzomib had antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. One should store this drug at 2°C to 8°C; 36°F to 46°F.
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