River of Flame has clustered monsters and lava that only a Barbarian with Leap or a Sorceress using Teleport could use to their advantage D2R ladder items. And, on top of that Hephasto, the Armor has a constant desire to kill the players. If they can overcome these obstacles then they'll get a handsome reward.

Chaos Sanctuary a.k.a. Diablo Run (Act 4)In the scenario that they don't find something significant or valuable at the River of Flame, players have the option of moving on to the second major area which is Diablo's home, Chaos Sanctuary. Also, it has some of the most powerful and most generous enemies in the game.

If the monsters don't drop anything eye-catching, then Diablo himself most likely will. It's a good thing that Diablo isn't too difficult to kill. Diablo's attacks are easy avoid and even a budget Bonemancer build can deal with him.

of the Damned. Act 4. Of The Damned (Act 4)The enemies in the City of the Damned are among the easiest of the whole late game to destroy buy diablo II resurrected items. They are relying on elemental and poison immunity, which is why an Sorceress or Poison Nova Necromancer might wish to avoid the city, however physical damage dealers can slice through the mobs like butter.