Local drug delivery has been explored in several areas, including the eye, the teeth, the female reproductive tract, and the prosthetic heart valves. Several articles published in early volumes of the Journal of Controlled Release describe local drug delivery in tissues and skin. These early reports have paved the way for future research in this field. Several articles published recently have shown local drug delivery in the eye, on prosthetic heart valves, and on the surface of a female reproductive tract.


FTIR spectroscopy for local drug
FTIR spectroscopy is a powerful technique for studying how a drug can penetrate the skin. It can reveal a variety of properties, from how well a drug dissolves in water to how much HPMC is present in the product. This type of analysis can be applied to a variety of drug delivery systems, including topical and local drug applications. FTIR imaging requires very little sample preparation time and can be used in the same manner as conventional dissolution tests.

FTIR spectroscopy has also been used to investigate biopharmaceuticals. Several examples include mAbs, which are highly specific and stable. They are classified into three categories: monoclonal antibodies (mAbs), bispecific antibodies (BSAs), and Fc-fusion proteins. These biopharmaceuticals pose unique challenges and require monitoring of higher order structures. FTIR spectroscopy is one of the most accurate and efficient techniques for local drug analysis.

In addition to local drug analysis, FTIR spectroscopy can also be used to characterise biopharmaceuticals and other drugs. FTIR spectroscopy can determine the primary and secondary structure of biopharmaceuticals, and it is also capable of detecting PTM changes in biopharmaceuticals. It can help you determine whether the drug is working as intended. The following are some benefits of FTIR spectroscopy for local drug analysis:

Targets for local drug delivery
There is an increasing need for advancements in drug delivery methods to the inner ear. The prevalence of diseases related to the inner ear, such as sensorineural hearing loss, is spurring efforts to develop therapeutic compounds and regenerative approaches. As the development of nanoparticles for drug delivery increases, so does the need to improve the delivery system for these compounds. Here are some of the latest developments in the field of local drug delivery.

A key characteristic of controlled release systems for local drug delivery is that they allow the greatest fraction of the drug molecules to reach the targeted tissue. The major disadvantage of systemic drug delivery is that it results in inadequate doses in the target tissue, and toxicity in the healthy tissues around the site of action. Local drug delivery systems are widely studied for local therapy in various fields, including brain tumors, vascular diseases, reproductive health, and wound healing. The major challenge in designing and engineering local drug delivery systems is sustained drug release in the target tissue while minimizing any adverse effects on the healthy surrounding tissue.

A new study combines ultrasound and a microfabricated needle electrode to deliver therapeutic agents to local tumors. This combination is capable of causing the microbubbles to pop, thereby increasing the uptake of drugs in the target tissues. The researchers tested various combinations of these devices. When compared to the conventional methods, this new technique is more efficient in the delivery of drugs in the skin. This study has important implications for the future of local drug delivery.

Case studies of drug-dealing sites in London
Local drug-dealing sites in London have been subject to less research than crack houses in other parts of the world. The authors of one such study, Webster et al. (2001), noted that a number of functional types of crack houses exist in the UK. The 'takeover' crack house model is common among dealers, which is also known as 'cuckooing.' Dealers also set up shop in provincial towns, far from their native urban centers.

The second study, carried out by the same author in Wiltshire, draws on 18 interviews with drug market actors. These drug market actors were employed by County Lines dealers and regularly bought drugs from them. Key person interviews and stand-alone observations were used to supplement the data collected. The author conducted fieldwork in three locations in Wiltshire, including a drug service, a local charity, and a street sex market.

The study also reveals that the influx of outside dealers made the victims vulnerable to the'moral economy' of local drug-dealing sites. Despite the widespread use of drugs, the vast majority of victims remain unprotected and opportunistic. While the influx of outside dealers created a greater risk for victims, County Lines dealers exploited the local crack and heroin'moral economy', resulting in an increase in murders.