Sulfamic acid is primarily a precursor of sweet compounds. It reacts with cyclohexylamine, and then NaOH is added to get C6H11NHSO3Na, cyclamate. Related compounds are also sweeteners, such as potassium acetosulfonate.

Sulfonates have been used in the design of a wide range of therapeutic agents, such as antibiotics, nucleoside/nucleotide human immunodeficiency virus (HIV) reverse transcriptase inhibitors, HIV protease inhibitors (PI), anticancer drugs (steroid sulfase and carbonic anhydrase inhibitors), antiepileptic drugs and weight-loss drugs.

Sulfamic acid is used as an acid cleaner and scale remover, sometimes pure or as an ingredient in proprietary mixtures, and is commonly used in metals and ceramics. For cleaning purposes, there are different grades depending on the application, such as GP grade, SR grade, and TM grade. Often used for rust removal, scale removal, instead of more volatile, more irritating hydrochloric acid, the price is cheaper. It is often used as an ingredient in household scale removers, for example, lime-A-way thick gels containing up to 8% sulfamic acid with A pH of 2.0 -- 2.2, or cleaners used to remove scale. Compared with most common strong inorganic acids, sulfamic acid has ideal water descaling properties, low volatility and low toxicity. It forms a water-soluble salt of calcium and iron trivalent.

Because of its inherent safety, sulfamic acid is superior to hydrochloric acid in home use. If inadvertently mixed with a bleach based product like hypochlorite, it won't form chlorine gas, as the most common acids do; As described in the previous section, the reaction (neutralization) with ammonia produces salt.

It can also be used for industrial cleaning of dairy products and saccharification equipment. Although it is considered less corrosive than hydrochloric acid, corrosion inhibitors are commonly added to commercial cleaners in which it is an ingredient. It can be used with coffee machine and espresso machine scale remover and denture cleaner scale remover.

Other USES
Catalyst for esterification process
Dye and pigment manufacturing
Urea - formaldehyde resin coagulant
Ingredients in fire extinguishing agent. Sulfamic acid is the main raw material for ammonium sulfamate, a herbicide and flame retardant widely used in household products.
Pulp and paper industry as chloride stabilizer
Reacts with nitric acid to synthesize nitrous oxide
The deprotonated form (sulfamate) is a common counterweight ion for nickel (II) in electroplating.
Brown ring test is used to separate nitrite ions from the mixture of nitrite and nitrate ion (NO3-+ NO2-) when qualitative analysis of nitrate is carried out.

Silver polishing
According to labels on consumer products, the silver cleaning product TarnX contains thiourea, cleanser and sulfamic acid.

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