The majority of research studies evaluated moderate to serious wrinkles; imply duration of therapy was 20 weeks. BontA therapy decreases creases within 4 weeks of treatment, however possibly increases danger of ptosis. The certainty of the proof for performance end results was high, reduced or moderate; for AEs, extremely low to modest. Future RCTs should contrast the most common BontA and review long-term end results. There is a lack of proof concerning the effects of numerous cycles lip injections - hopecosmetics.ca of BontA, frequency of major AEs, duration of result, efficacy of recently-approved BontA and also contrasts with various other therapies.