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Neuropathological changes differentiate FRDA from other hereditary ataxias 10 ().Loss of large primary neurons in dorsal root ganglia is a prominent and early hallmark. Historical note: The most famous pioneer in the descriptive anatomy of nerve cells was Ramón y Cajal. Cajal introduced the four principles which comprise the neuron doctrine (quotes are from Kandel 2006, In Search of Memory, pp. 65-66): . Cellularity: "The nerve cell is the fundamental structural and functional element of the brain." 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