Medical services experts suggest the utilization of the medication Polymyxin B to treat diseases when brought about by vulnerable types of the assigned high-impact gram-negative microscopic organisms: Urinary plot contaminations, Circulatory system contaminations, Meningeal diseases and Corneal and subconjunctival eye diseases. Polymyxin B is one of a gathering of fundamental polypeptide anti-microbials got from B polymyxa (B aerosporous). The medication Polymyxin B sulfate has a bactericidal activity against practically all gram-negative bacilli with the exception of the Proteus bunch. Polymyxins increment the penetrability of the bacterial cell film, prompting the cell's passing. This medication is accessible in 500000 IU for intramuscular, intravenous trickle, intrathecal, or ophthalmic use.