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Posted by House of Kalra on April 29, 2024 at 8:34am 0 Comments 0 Likes
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3), the sites of protonation are N1 of adenosine and N3 of cytidine. At more acidic pH, the N7 of guanosine and adenosine and the O4 of uridine are protonated. Thus, all the bases remain mostly uncharged in the physiological range of pH 5 to 9 (Saenger, 1984). It is noteworthy that each of the nucleosides A, C, and G becomes protonated at one of the ring nitrogens rather than on the exocyclic amino group. Thus, the electron pair of the amino group can delocalize into the heteroaromatic ring. Indeed the C–NH2 bonds of A, C, and G are.
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