The most common benign tumor affecting the main salivary glands is Pleomorphic Adenoma, which rarely comes from the smaller salivary glands. The parotides of the main salivary glands and the palate of small salivary glands are included. Neoplasms of the salivary gland can occur anywhere there is salivary tissue. The palate is the most frequent intraoral site, followed by the cheek and very rarely in the top lip among small salivary glands. The lesion occurs clinically as a dome-shaped mass with a smooth surface that is painless and slow-growing. The microscopy shows a mix of the glandular epithelial and myoepithelial cells in a mesenchymal environment. The treatment involves operative excision to the base periosteum.
Pleomorphic adenoma is the most common tumor with complex histomorphological characteristics of the salivary gland. Early diagnosis and treatment requirea detailed history, clinical examination, radiological and histopathological evidence.Salivary gland tumors are most likely the most complex among human neoplasms because they present a wide histological spectrum due to the differentiation of several tumor cells, cellular arrangements, and the extracellular matrix of certain tumor cells. The salivary gull tumors correspond to 3 percent in the head-and-neck areas, the bulk of which are epithelial, have varied etiologies and several identified risk factors so far. Pleomorphic adenoma, which accounting for almost 50% of all neoplasms in the head and neck region, is the most common salivary gland tumor. Its name comes from the light microscope architectural pleomorphism. Very little research has been carried out on histomorphological results of the salivary gland pleomorphic adenoma.