Those who have received all required jabs can ditch their face coverings if alone or in small groups of vaccinated people, the new guidelines say.
But the CDC left in place its guidance to don a mask indoors and in crowded settings or venues.Over 95 million Americans have been fully vaccinated thus far.
Following the CDC announcement on Tuesday, President Joe Biden celebrated the new guidance as "extraordinary progress".

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Health officials have noted that the case count in the US is stabilising as the rate of vaccinations continues to grow, and on Tuesday, they called for more people to sign up for vaccinations.
Nearly 141 million Americans - about 42% of the total population - have received at least one vaccine dose as of 26 April, according to the CDC.