The diagnosis of asthma is difficult and even more so in children. In asthma, one of the disease's hallmarks is airway hyperresponsiveness, or also known as AHR, which correlates with the disease severity and is defined as increased sensitivity and reactivity to airways to numerous stimuli. Airway hyperresponsiveness is assessed by exposing patients to either direct stimuli, such as histamine and methacholine, or indirect stimuli such as exercise or bradykinin.

Provocholine is a…

The diagnosis of asthma is difficult and even more so in children. In asthma, one of the disease's hallmarks is airway hyperresponsiveness, or also known as AHR, which correlates with the disease severity and is defined as increased sensitivity and reactivity to airways to numerous stimuli. Airway hyperresponsiveness is assessed by exposing patients to either direct stimuli, such as histamine and methacholine, or indirect stimuli such as exercise or bradykinin.

Provocholine is a…